Estradiol monitoring in women on menopausal hormone therapy remains one of the more contested — and underutilized — practices in clinical menopause care. In this session, Drs. Sarah Glynne and James Simon build the clinical case for when and why estradiol level assessment matters: from optimizing symptom relief and avoiding undertreatment to informing individualized dosing decisions and managing safety in complex patients, including those with a breast cancer history. Drawing on both the evidence base and extensive clinical experience across distinct practice settings, they will offer a practical, nuanced framework for integrating estradiol monitoring into hormone therapy management — and examine what the data actually supports versus where clinical judgment must fill the gaps.

James A. Simon, MD, CCD, MSCP, IF, FACOG, is a board-certified obstetrician-gynecologist and reproductive endocrinologist in Washington, D.C., and Clinical Professor of Obstetrics and Gynecology at The George Washington University School of Medicine. A nationally and internationally recognized leader in women's health, Dr. Simon has served as Principal Investigator on more than 400 clinical trials, research grants, and scholarships, and has authored more than 800 published articles, abstracts, and chapters, as well as the book Restore Yourself: A Woman's Guide to Reviving Her Sexual Desire and Passion for Life. His clinical expertise spans the full reproductive lifespan, with deep specialization in menopause, sexual health, and hormone therapy.

Sarah Glynne, MBChB, MRCOG, is a UK-based Consultant Gynaecologist and Menopause Specialist practicing across NHS and private settings, with recognized expertise in complex menopause care — including for women with a history of breast cancer. Her clinical work centers on evidence-based, individualized decision-making in hormone therapy, with particular focus on balancing symptom management, sexual health, and quality of life against oncologic safety considerations. Dr. Glynne is known for her ability to guide women through nuanced hormonal treatment decisions with clinical precision and clarity.